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Houston Astros at Cleveland Guardians

MLB · Wednesday, April 22, 2026

Houston Astros81-812

@

Final

Cleveland Guardians85-770

Houston Astros won 2-0 on April 22, 2026 at Progressive Field.

Date: Wed, Apr 22 · 1:10 PM ET
Venue: Progressive Field, Cleveland
League: MLB · Regular season
Scores that day: MLB scores, Apr 22, 2026 · All leagues

Houston Astros

Record 81-81 · Last 5: L L L W L

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Cleveland Guardians

Record 85-77 · Last 5: L W W L W

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Astros vs Guardians this season

AstrosHOU9

GuardiansCLE2Mon, Apr 20 · Final

AstrosHOU5

GuardiansCLE8Tue, Apr 21 · Final

GuardiansCLE3

AstrosHOU9Fri, Jun 19 · Final

GuardiansCLE8

AstrosHOU1Sat, Jun 20 · Final

GuardiansCLE1

AstrosHOU2Sun, Jun 21 · Final