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Houston Astros at Cleveland Guardians

MLB · Tuesday, April 21, 2026

Houston Astros81-815

@

Final

Cleveland Guardians85-778

Cleveland Guardians won 8-5 on April 21, 2026 at Progressive Field.

Date: Tue, Apr 21 · 6:10 PM ET
Venue: Progressive Field, Cleveland
League: MLB · Regular season
Scores that day: MLB scores, Apr 21, 2026 · All leagues

Houston Astros

Record 81-81 · Last 5: L L L L W

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Cleveland Guardians

Record 85-77 · Last 5: W L W W L

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Astros vs Guardians this season

AstrosHOU9

GuardiansCLE2Mon, Apr 20 · Final

AstrosHOU2

GuardiansCLE0Wed, Apr 22 · Final

GuardiansCLE3

AstrosHOU9Fri, Jun 19 · Final

GuardiansCLE8

AstrosHOU1Sat, Jun 20 · Final

GuardiansCLE1

AstrosHOU2Sun, Jun 21 · Final